Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. This patient infected with granuloma inguinale, also known as donovanosis, presented with a perianal ulceration. Case report cholesterol granuloma of paratesticular tissue. Granuloma inguinale is a progressive ulcerative disease that is usually sexually transmitted and involves the skin and subcutaneous tissues in the anogenital and inguinal regions. Granuloma inguinale merck manuals consumer version. If left untreated, this bacteriumrelated cutaneous condition can permanently scar the genitals, and even destroy the tissue of the genitals. Donovanosis is a predominantly tropical cause of genital ulcer occurring chiefly in small endemic foci in all continents except europe. A class of bacteria known as klebsiella granulomatis causes this infection.
Granuloma inguinale granuloma inguinale, male granuloma inguinale, female granuloma inguinale, chronic destructive lesion granuloma inguinale with both active and healed lesions granuloma inguinale, donovan bodies granuloma inguinale granuloma inguinale, male granuloma inguinale, female granuloma inguinale, chronic destructive lesion granuloma inguinale with both active and healed lesions. Klebsiella granulomatis is the bacteria responsible for granuloma inguinale. Please use one of the following formats to cite this article in your essay, paper or report. Ulcera genital por klebsiella granulomatis donovanosis.
Granuloma inguinale is a sexually transmitted disease std believed to be caused by bacteria calledcalymmatobacterium granulomatis donovania granulomatis. Granuloma inguinal new york state department of health. The disease is commonly known as donovanosis, after the donovan bodies seen on microscopy, which are a diagnostic sign. Granuloma inguinale infectious diseases merck manuals. The disease is rare in the western world but is a major cause of genital ulcer in southeast india, brazil and some parts of africa. Donovanosis or granuloma inguinale is caused by infection with klebsiella granulomatis, formerly known as donovania granulomatis, and calymmatobacterium granulomatis, and was recently renamed following comparative dna sequencing studies. These slides may contain graphic images ofsexually transmitted diseases intended for educational and teaching purposes, and may not be appropriate for all audiences.
Granuloma inguinale donovanosis 2015 std treatment guidelines. Granuloma inguinale infectious diseases msd manual. It leads to chronic inflammation and scarring of the genitals. The granuloma inguinale elimination program among aborigines in australia appears to be. It has also been known as donovanosis, granuloma contagiosa, granuloma pudendi tropicum, sclerosing granuloma, and other synonyms, which are now archaic. Diagnosis requires the careful collection, staining and examination of smears or biopsies of characteristic genital. This work is licensed under the creative commons attribution 4. In 2012, cdc staff and workgroup members were charged with identifying key questions regarding. Granuloma inguinale definition is a sexually transmitted disease characterized by ulceration and formation of granulations on the genitalia and in the groin area and caused by a bacterium calymmatobacterium granulomatis synonym donovania granulomatis. Granuloma inguinale centers for disease control and. Internal medicine clinical treatment guidelines 9 10 2012. Click here for the professional version click here for the professional version granuloma inguinale is a rare sexually transmitted disease caused by the bacteria klebsiella granulomatis.
Granuloma annulare genetic and rare diseases information. The case of inguinal granuloma that justifies this report was developed by a caucasian man who had a sexual relation with a. Started in 1995, this collection now contains 6767 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. The diagnosis and treatment of donovanosis granuloma. It is a chronic infection of the skin and lymph glands in the genital area of the body. Sexually transmitted diseases treatment guidelines, 2015 cdc. Pdf inguinal hernia with incidental parasitic infection. Several distinct subtypes have been recognized, namely localized granuloma. Granuloma inguinale is an sti, and you can contract it by having vaginal or anal intercourse with an infected partner.
Granuloma inguinale msd manual professional edition. Diagnosis and management of granuloma annulare peggy r. Granuloma inguinale, or donovanosis, is a rare, sexually transmitted ulcerative disease primarily affecting the genital area. Granuloma annulare is a benign, usually selflimited granulomatous disease of the dermis and subcutaneous tissue. Geographic distribution and magnitude of disease burden. Published by pacific group of ejournals page cholesterol granuloma of paratesticular tissue. Two cases of parasitic granuloma found incidentally in surgical specimens. In women, primary lesions of the cervix may lead to ascending infection of uterus and tubes. The disease is commonly found in tropical and subtropical areas such as southeast india, guyana, and new guinea. The most common consequences are spermatic granuloma. Granuloma inguinale, calymmatobacterium granulomatis, klebsiella granulomatis, donovanosis, donovan body, donovan bodies. Granuloma inguinale is a chronic bacterial infection that affect the skin and. Limitations include the lack of recent drug studies.
Granuloma inguinale definition, a venereal disease marked by deep ulceration of the skin of the groin and external genitals, caused by the bacterium calymmatobacterium granulomatis. The most common locations of granuloma inguinale lesions in men are the sulcocoronal and balanopreputial regions, as well as the anus. Iatrogenic vas deferens injury due to inguinal hernia repair. Donovanosis granuloma inguinale is a sexually transmitted disease that is rarely seen in the united states. Tissue sample from a granuloma inguinale lesion, shows a white blood cell containing the pathognomonic finding of donovan bodies, which are encapsulated, gramnegative rods, representing the responsible bacterium klebsiella granulomatis. Tropical and semitropical india, papua new guinea, australia, carribean, africa. Male genital tract injuries after contemporary inguinal hernia repair. Granuloma inguinale donovanosis is a rare genital ulcerative bacterial infection that is usually found in tropical or subtropical areas. Biradar2, safarulla and suraksha rao b1 1department of pathology, sapthagiri institute of medical sciences and research centre, bangalore, india. In australia, it is largely confined to aboriginal and torres strait islander population in the remote northern region. June 2012 the american journal of dermatopathology. Subcutaneous extension into the inguinal area results in induration that can mimic inguinal adenopathy ie, pseudobubo. The initial nodule slowly enlarges, erodes the surrounding tissues, and develops into a beefy, bulky, granulomatous mass. Its name is derived from granuloma, a medical term for a mass or growth of granulation tissue, and inguinale, a latin word that means located in the groin.
Marked reactive changes in surface epithelium secondary to inflammation and ulceration. Granuloma inguinale is characterized by intracellular inclusions in macrophages referred to as donovan bodies. In women, granuloma inguinale lesions occur on the labia minora, the mons veneris, the fourchette, andor the cervix. Granuloma inguinale is a mildly contagious disease of chronic ulcerative granulomatous lesions affecting primarily the skin and subcutaneous tissues and found only in man. Granuloma inguinale is a bacterial disease caused by klebsiella granulomatis formerly known as calymmatobacterium granulomatis characterized by genital ulcers. Inguinal hernias occur at the inguinal canal in the groin region. Granuloma inguinale definition granuloma inguinale is a sexually transmitted infection that affects the skin and mucous membranes of the anal and genital areas. Granuloma inguinale is a chronic bacterial infection that frequently is associated with other sexually transmitted diseases. Dynamed topics are created and maintained by the dynamed editorial team and process. This female presented with a left inguinal lymph node infection due to what was diagnosed as a granulomatis inguinale.
Granuloma inguinale, or donovanosis, is a chronic, slowly destructive. Granuloma inguinale in a 51yearold man escholarship. Granuloma inguinale, was first described and named serpiginous ulcer by mcleod et al. Mainly on the vulva, urethra, perineumanal area and inguinal region. Granuloma inguinale is a sexually transmitted bacterial disease that affects the skin of the groin. Granuloma annulare ga is skin disorder that most often causes a rash with red bumps erythematous papules arranged in a circle or ring pattern annular. Files are available under licenses specified on their description page. Persons with both granuloma inguinale and hiv infection should receive.
The proper clinical designation for donovanosis is granuloma inguinale. All structured data from the file and property namespaces is available under the creative commons cc0 license. Granuloma inguinale an overview sciencedirect topics. A granuloma is a nodular type of inflammatory reaction, and inguinale refers to the inguinal region, which is commonly involved in this infection. The first use of the term granuloma inguinale is not known, but is believed to be derived from the anatomic description as follows.
A successful elimination program in australia targeting. This page includes the following topics and synonyms. Granuloma inguinale donovanosis is caused by calymmatobacterium granulomatis. Chancroid, lymphogranuloma venereum, granuloma inguinale. Pdf inguinal hernia repair is a common and straightforward surgical procedure. Percent of women who said topic was discussed during first. Granuloma inguinale donovanosis clinical presentation. The clinical conditions included in this manual were selected based on. Granuloma inguinale is most commonly found in tropical or subtropical areas such as papua new guinea, southern india, southern africa, the caribbean and south america. It is also known as donovanosis, granuloma genitoinguinale, granuloma inguinale tropicum, granuloma venereum, granuloma venereum genitoinguinale, lupoid form of groin ulceration. The donovanosis or granuloma inguinale is an infectious, chronic inflammatory and usually ulcerative disease, preferentially of anogenital location, that is sexually transmitted and caused by the bacteria klebsiella granulomatis. Granuloma inguinale usually affects the skin and mucous membranes in the genital region, where it results in. Localized ga is the most common form of ga 75% of the cases and usually affects the forearms, hands, or feet. Reference bashh 2018 united kingdom national guideline on management of donovanosis granuloma inguinale bashh 2018 pdf dynamed editorial process.
This female presented with granuloma inguinale exhibiting bilateral inguinal node involvement due to c. Granuloma inguinale typically causes red lesions to appear on the genital, anus, and inguinal folds, where the legs attach to the trunk. Granuloma inguinale donovanosis 2015 std treatment. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. Choose from 124 different sets of granuloma flashcards on quizlet. The addition of another antibiotic to these regimens can be considered if. Verrucous, necrotic, and fibrous lesions may occur as well. Granuloma inguinale definition of granuloma inguinale at. It is characterized by the presence of the donovan bodies in the microscopy. Granuloma inguinale definition of granuloma inguinale by.
44 620 1160 461 1133 1338 1189 1538 597 1068 1346 1048 637 78 555 386 644 586 992 380 401 961 742 530 1145 782 165 707 1116 807 1303 1352 1193 1103